JF-NP-26
JF-NP-26, an inactive photocaged derivative of raseglurant, is the first caged mGlu5 receptor negative allosteric modulator. Uncaging of JF-NP-26 is elicited with light pulses in the visible spectrum (405 nm) . JF-NP-26 induces light-dependent analgesia in models of inflammatory and neuropathic pain in freely behaving animals[1].
Product Specifications
CAS Number
2341841-03-8
UNSPSC
12352005
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/jf-np-26.html
Solubility
10 mM in DMSO
Smiles
O=C(OCC(C1=CC=C(N(CC)CC)C=C1O2)=CC2=O)NC3=C(C)C=C(C)N=C3C#CC4=CC=CC(F)=C4
Molecular Formula
C30H28FN3O4
Molecular Weight
513.56
References & Citations
[1]Font J, et al. Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator [published correction appears in Elife. 2018 Jan 08;7:]. Elife. 2017;6:e23545. Published 2017 Apr 11.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR5
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
![5-Formyl-2-[(2-nitrophenyl)amino]-3-cyanothiophene](https://cdn.genprice.uk/products/572/2342131289323/imageurl/trc-f700860-25mg.webp)
TRC-F700860-25MG 25 mg
5-Formyl-2-[(2-nitrophenyl)amino]-3-cyanothiophene
Sign In for Pricing
View Details 
BNUM1655-50 1x 50 µL
NKX2.2 (Neuroendocrine & Ewing's Sarcoma Marker), 1mg/mL
Sign In for Pricing
View Details 
LY403069 100 µg
MEK2 (MAP2K2) (NM_030662) Human Over-expression Lysate
Sign In for Pricing
View Details 