IHR-Cy3

IHR-Cy3 is a potent fluorescent Smo antagonist with an IC50 of 100 nM[1].

Product Specifications

UNSPSC

12352005

Target

Smo

Type

Reference compound

Related Pathways

Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ihr-cy3.html

Solubility

10 mM in DMSO

Smiles

ClC1=CC=C(C(C(NC2=CC=C(C=C2)NC(C3=C(C=CC(NC(CCCCCCNC(CCCCC[N+]4=C(C(C)(C5=C4C=CC(S(=O)(O)=O)=C5)C)/C=C/C=C6N(C7=C(C/6(C)C)C=C(S(=O)([O-])=O)C=C7)CC)=O)=O)=C3)Cl)=O)=O)=C1)Cl

Molecular Formula

C58H63Cl3N6O10S2

Molecular Weight

1174.64

References & Citations

[1]Chih-Wei Fan, et al. The Hedgehog Pathway Effector Smoothened Exhibits Signaling Competency in the Absence of Ciliary Accumulation. Chem Biol

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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