Ipatasertib-NH2 (dihydrochloride)
Ipatasertib-NH2 dihydrochloride is a ligand for target protein AKT for PROTAC (INY-03-041) . INY-03-041 is composed of Ipatasertib-NH2, a ten-hydrocarbon linker, and a CRBN ligand Lenalidomide for E3 ubiquitin ligase[1].
Product Specifications
CAS Number
[1001264-73-8]
Product Name Alternative
GDC-0068-NH2 (dihydrochloride) ; RG7440-NH2 (dihydrochloride)
UNSPSC
12352005
Target
Ligands for Target Protein for PROTAC
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ipatasertib-nh2-dihydrochloride.html
Solubility
10 mM in DMSO
Smiles
C[C@H]1C2=C(N3CCN(CC3)C([C@@H](C4=CC=C(C=C4)Cl)CN)=O)N=CN=C2[C@@H](C1)O.Cl.Cl
Molecular Formula
C21H28Cl3N5O2
Molecular Weight
488.84
References & Citations
[1]You I, et al. Discovery of an AKT Degrader with Prolonged Inhibition of Downstream Signaling. Cell Chem Biol. 2020 Jan 16;27 (1) :66-73.e7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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