Ipatasertib-NH2 (dihydrochloride)
Product Specifications
UNSPSC Description
Ipatasertib-NH2 dihydrochloride is a ligand for target protein AKT for PROTAC (INY-03-041). INY-03-041 is composed of Ipatasertib-NH2, a ten-hydrocarbon linker, and a CRBN ligand Lenalidomide for E3 ubiquitin ligase[1].
Target Antigen
Ligands for Target Protein for PROTAC
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ipatasertib-nh2-dihydrochloride.html
Solubility
10 mM in DMSO
Smiles
C[C@H]1C2=C(N3CCN(CC3)C([C@@H](C4=CC=C(C=C4)Cl)CN)=O)N=CN=C2[C@@H](C1)O.Cl.Cl
Molecular Weight
488.84
References & Citations
[1]You I, et al. Discovery of an AKT Degrader with Prolonged Inhibition of Downstream Signaling. Cell Chem Biol. 2020 Jan 16;27(1):66-73.e7.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-130988A/Ipatasertib-NH2-dihydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-130988A/
Clinical Information
No Development Reported
CAS Number
1001264-73-8
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