Ipatasertib-NH2 (dihydrochloride)

Ipatasertib-NH2 dihydrochloride is a ligand for target protein AKT for PROTAC (INY-03-041) . INY-03-041 is composed of Ipatasertib-NH2, a ten-hydrocarbon linker, and a CRBN ligand Lenalidomide for E3 ubiquitin ligase[1].

Product Specifications

CAS Number

[1001264-73-8]

Product Name Alternative

GDC-0068-NH2 (dihydrochloride) ; RG7440-NH2 (dihydrochloride)

UNSPSC

12352005

Target

Ligands for Target Protein for PROTAC

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ipatasertib-nh2-dihydrochloride.html

Solubility

10 mM in DMSO

Smiles

C[C@H]1C2=C(N3CCN(CC3)C([C@@H](C4=CC=C(C=C4)Cl)CN)=O)N=CN=C2[C@@H](C1)O.Cl.Cl

Molecular Formula

C21H28Cl3N5O2

Molecular Weight

488.84

References & Citations

[1]You I, et al. Discovery of an AKT Degrader with Prolonged Inhibition of Downstream Signaling. Cell Chem Biol. 2020 Jan 16;27 (1) :66-73.e7.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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