Mal-PEG4-bis-PEG3-DBCO
Product Specifications
UNSPSC Description
Mal-PEG4-bis-PEG3-DBCO is a cleavable 7 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Mal-PEG4-bis-PEG3-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
Target Antigen
ADC Linker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mal-peg4-bis-peg3-dbco.html
Solubility
10 mM in DMSO
Smiles
O=C(CCOCCOCCOCCOCCNC(CCN1C(C=CC1=O)=O)=O)NC(COCCC(NCCOCCOCCOCCNC(CCC(N2C(C=CC=C3)=C3C#CC(C=CC=C4)=C4C2)=O)=O)=O)COCCC(NCCOCCOCCOCCNC(CCC(N5C(C=CC=C6)=C6C#CC(C=CC=C7)=C7C5)=O)=O)=O
Molecular Weight
1556.75
References & Citations
[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-130971/Mal-PEG4-bis-PEG3-DBCO-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-130971/
Clinical Information
No Development Reported
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