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Mal-PEG4-bis-PEG3-DBCO

Mal-PEG4-bis-PEG3-DBCO is a cleavable 7 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. Mal-PEG4-bis-PEG3-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

Product Specifications

CAS Number

[2882973-10-4]

UNSPSC

12352203

Hazard Statement

H302-H315-H319-H335

Target

ADC Linker

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mal-peg4-bis-peg3-dbco.html

Solubility

10 mM in DMSO

Smiles

O=C(CCOCCOCCOCCOCCNC(CCN1C(C=CC1=O)=O)=O)NC(COCCC(NCCOCCOCCOCCNC(CCC(N2C(C=CC=C3)=C3C#CC(C=CC=C4)=C4C2)=O)=O)=O)COCCC(NCCOCCOCCOCCNC(CCC(N5C(C=CC=C6)=C6C#CC(C=CC=C7)=C7C5)=O)=O)=O

Molecular Formula

C81H105N9O22

Molecular Weight

1556.75

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16 (5) :315-337.

Shipping Conditions

Room temperature

Scientific Category

ADC Related

Clinical Information

No Development Reported

Isoform

Cleavable Linker

Curated Selection

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