DBCO-Val-Cit-PABC-OH
Product Specifications
UNSPSC Description
DBCO-Val-Cit-PABC-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. DBCO-Val-Cit-PABC-OH is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
Target Antigen
ADC Linker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dbco-val-cit-pabc-oh.html
Solubility
10 mM in DMSO
Smiles
O=C(N1C2=C(C#CC3=C(C1)C=CC=C3)C=CC=C2)CCCCC(N[C@H](C(N[C@H](C(NC4=CC=C(C=C4)CO)=O)CCCNC(N)=O)=O)C(C)C)=O
Molecular Weight
694.82
References & Citations
[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-130936/DBCO-Val-Cit-PABC-OH-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-130936/
Clinical Information
No Development Reported
Curated Selection
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