DBCO-NH- (CH2) 4COOH
DBCO-NH- (CH2) 4COOH is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DBCO-NH- (CH2) 4COOH is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
Product Specifications
CAS Number
[2375193-74-9]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
PROTAC Linkers
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dbco-nh-ch2-4cooh.html
Purity
98.15
Solubility
10 mM in DMSO
Smiles
OC(CCCCC(NCCC(N1CC2=C(C#CC3=C1C=CC=C3)C=CC=C2)=O)=O)=O
Molecular Formula
C24H24N2O4
Molecular Weight
404.46
Precautions
H302, H315, H319, H335
References & Citations
[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Alkyl-Chain Linkers
Available Sizes
Curated Selection
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