Thalidomide-NH-C4-NH2 (TFA)

Thalidomide-NH-C4-NH2 TFA (compound 29c) is an E3 ligase ligand-linker conjugate, and incorporates the Thalidomide based cereblon ligand and a linker. Thalidomide-NH-C4-NH2 TFA is used in PROTAC BRD2/BRD4 degrader-1 (HY-130612) . PROTAC BRD2/BRD4 degrader-1 is a potent and selective BET protein BRD4 and BRD2 degrader[1].

Product Specifications

CAS Number

[2093387-50-7]

UNSPSC

12352005

Hazard Statement

H360

Target

Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/thalidomide-nh-c4-nh2-tfa.html

Solubility

10 mM in DMSO

Smiles

O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3NCCCCN)=O.O=C(O)C(F)(F)F

Molecular Formula

C19H21F3N4O6

Molecular Weight

458.39

Precautions

P280-P405-P501

References & Citations

[1]Jiang F, et al. Discovery of novel small molecule induced selective degradation of the bromodomain and extra-terminal (BET) bromodomain protein BRD4 and BRD2 with cellular potencies. Bioorg Med Chem. 2020 Jan 1;28 (1) :115181.