BET-IN-6
Product Specifications
UNSPSC Description
BET-IN-6 is a potent and high affnity BRD2/BRD4 inhibitor. BET-IN-6 is the ligand for target protein BRD2/4, and is used for the systhesis of PROTAC BRD2/BRD4 degrader-1 (HY-130612)[1].
Target Antigen
Epigenetic Reader Domain; Ligands for Target Protein for PROTAC
Type
Reference compound
Related Pathways
Epigenetics;PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bet-in-6.html
Solubility
10 mM in DMSO
Smiles
O=C(O)CCC1=CC2=C(C=CC(N(C3=O)C)=C2C3=C1)NS(=O)(C4=CC=CC=C4OC)=O
Molecular Weight
440.47
References & Citations
[1]Jiang F, et al. Discovery of novel small molecule induced selective degradation of the bromodomain and extra-terminal (BET) bromodomain protein BRD4 and BRD2 with cellular potencies.Bioorg Med Chem. 2020 Jan 1;28(1):115181.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-130813/BET-IN-6-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-130813/
Clinical Information
No Development Reported
CAS Number
2570470-39-0
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
RC206288L3V 200 µL
Ceramide glucosyltransferase (UGCG) (NM_003358) Human Tagged ORF Clone Lentiviral Particle
Ask
View Details 
RC217903L4 10 µg
Phospholipase C beta 4 (PLCB4) (NM_182797) Human Tagged Lenti ORF Clone
Ask
View Details