BET-IN-6
BET-IN-6 is a potent and high affnity BRD2/BRD4 inhibitor. BET-IN-6 is the ligand for target protein BRD2/4, and is used for the systhesis of PROTAC BRD2/BRD4 degrader-1 (HY-130612) [1].
Product Specifications
CAS Number
[2570470-39-0]
UNSPSC
12352005
Target
Epigenetic Reader Domain; Ligands for Target Protein for PROTAC
Type
Reference compound
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bet-in-6.html
Solubility
10 mM in DMSO
Smiles
O=C(O)CCC1=CC2=C(C=CC(N(C3=O)C)=C2C3=C1)NS(=O)(C4=CC=CC=C4OC)=O
Molecular Formula
C22H20N2O6S
Molecular Weight
440.47
References & Citations
[1]Jiang F, et al. Discovery of novel small molecule induced selective degradation of the bromodomain and extra-terminal (BET) bromodomain protein BRD4 and BRD2 with cellular potencies.Bioorg Med Chem. 2020 Jan 1;28 (1) :115181.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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