BET-IN-6

BET-IN-6 is a potent and high affnity BRD2/BRD4 inhibitor. BET-IN-6 is the ligand for target protein BRD2/4, and is used for the systhesis of PROTAC BRD2/BRD4 degrader-1 (HY-130612) [1].

Product Specifications

CAS Number

[2570470-39-0]

UNSPSC

12352005

Target

Epigenetic Reader Domain; Ligands for Target Protein for PROTAC

Type

Reference compound

Related Pathways

Epigenetics; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/bet-in-6.html

Solubility

10 mM in DMSO

Smiles

O=C(O)CCC1=CC2=C(C=CC(N(C3=O)C)=C2C3=C1)NS(=O)(C4=CC=CC=C4OC)=O

Molecular Formula

C22H20N2O6S

Molecular Weight

440.47

References & Citations

[1]Jiang F, et al. Discovery of novel small molecule induced selective degradation of the bromodomain and extra-terminal (BET) bromodomain protein BRD4 and BRD2 with cellular potencies.Bioorg Med Chem. 2020 Jan 1;28 (1) :115181.