ALK/ROS1-IN-1
ALK/ROS1-IN-1 (compound 2e) is a potent and selective anti crizotinib-resistant ALK/ROS1 dual inhibitor, with IC50s of 0.174 μM and 0.530 μM for ALK and ROS1 enzyme, respectively.
Product Specifications
CAS Number
2365497-07-8
UNSPSC
12352005
Target
Anaplastic lymphoma kinase (ALK) ; ROS Kinase
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/alk-ros1-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C([C@H]1CCCN(C2=CC(NC3=CC=C(N4CCNCC4)C=C3OC)=NC=C2)C1)NCC5=CC=C(OC(F)(F)F)C=C5
Molecular Formula
C30H35F3N6O3
Molecular Weight
584.63
References & Citations
[1]Liu S, et al. Design, synthesis and biological evaluations of 2-amino-4- (1-piperidine) pyridine derivatives as novel anti crizotinib-resistant ALK/ROS1 dual inhibitors. Eur J Med Chem. 2019 Oct 1;179:358-375.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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