ThrRS-IN-1
ThrRS-IN-1 (Compound 30d) is a threonyl-tRNA synthetase (ThrRS) inhibitor with an IC50 of 1.4 µM and a Kd of 1.36 µM against Salmonella enterica ThrRS (SeThrRS) . ThrRS-IN-1 simultaneously targets the tRNAThr and L-threonine binding pockets of ThrRS. ThrRS-IN-1 shows potent antibacterial activities[1].
Product Specifications
CAS Number
2408626-64-0
UNSPSC
12352005
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/thrrs-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C1N(C/C=C/CNC([C@@H](N)[C@H](O)C)=O)C=NC2=CC(Cl)=C(Cl)C=C21
Molecular Formula
C16H18Cl2N4O3
Molecular Weight
385.25
References & Citations
[1]Junsong Guo, et al. Discovery of novel tRNA-amino acid dual-site inhibitors against threonyl-tRNA synthetase by fragment-based target hopping. Eur J Med Chem. 2020 Feb 1;187:111941.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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