(S, R, S) -AHPC-C3-NH2 (TFA)

(S, R, S) -AHPC-C3-NH2 TFA (VH032-C3-NH2 TFA) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology. (S, R, S) -AHPC-C3-NH2 can be used in the synthesis of a series of PROTACs, such as UNC6852 (HY-130708) . UNC6852 is an EED-targeted bivalent chemical degrader[1].

Product Specifications

CAS Number

[2688842-02-4]

Product Name Alternative

VH032-C3-NH2 (TFA)

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

E3 Ligase Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/s-r-s-ahpc-c3-nh2-tfa.html

Solubility

10 mM in DMSO

Smiles

OC(C(F)(F)F)=O.NCCCC(N[C@H](C(N1[C@@H](C[C@H](C1)O)C(NCC2=CC=C(C=C2)C3=C(N=CS3)C)=O)=O)C(C)(C)C)=O

Molecular Formula

C28H38F3N5O6S

Molecular Weight

629.69

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Potjewyd F, et al. Degradation of Polycomb Repressive Complex 2 with an EED-Targeted Bivalent Chemical Degrader. Cell Chem Biol. 2020 Jan 16;27 (1) :47-56.e15.