K-Ras ligand-Linker Conjugate 3
K-Ras ligand-Linker Conjugate 3 (Compound 001371) incorporates a ligand for K-Ras recruiting moiety, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 3 can be used in the synthesis of PROTAC K-Ras Degrader-1 , which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells[1].
Product Specifications
CAS Number
2378261-87-9
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Target Protein Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/k-ras-ligand-linker-conjugate-3.html
Solubility
10 mM in DMSO
Smiles
O=C(N1[C@@H](CC#N)CN(C2=C3C(CN(C4=C5C=CC=CC5=CC=C4)CC3)=NC(OC[C@H]6N(C)C[C@H](OCCOCCOCCOCCOS(=O)(C7=CC=C(C)C=C7)=O)C6)=N2)CC1)OC(C)(C)C
Molecular Formula
C49H65N7O10S
Molecular Weight
944.15
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Andrew P. Crew, et al. Modulators of proteolysis and associated methods of use. WO2019195609A2.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
ACTH (Adrenocorticotrophic Hormone) (AH26), CF594 conjugate, 0.1mg/mL
Complement C4d (C4D204), CF647 conjugate, 0.1mg/mL
Eosinophil Peroxidase (AHE-1), CF740 conjugate, 0.1mg/mL
