PERK-IN-3
PERK-IN-3 is a potent PERK inhibitor with an IC50 of 7.4 nM[1].
Product Specifications
CAS Number
1337532-08-7
UNSPSC
12352005
Target
PERK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/perk-in-3.html
Solubility
10 mM in DMSO
Smiles
FC1=CC=C(F)C(CC(N2CCC3=C2C=CC(C4=COC5=NC=NC(N)=C54)=C3)=O)=C1
Molecular Formula
C22H16F2N4O2
Molecular Weight
406.38
References & Citations
[1]Axten JM , et al. Discovery of 7-methyl-5- (1-{[3- (trifluoromethyl) phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl) -7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR) -like endoplasmic reticulum kinase (PERK) . J Med Chem. 2012 Aug 23;55 (16) :7193-207.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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