PAK4-IN-1
PAK4-IN-1 (Compound 19) is a potent, selective, orally active PAK4 inhibitor with robust anti-tumor efficacy in vivo. PAK4-IN-1 is stable under both acidic and neutral conditions[1].
Product Specifications
CAS Number
2396529-58-9
UNSPSC
12352005
Target
PAK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pak4-in-1-1.html
Solubility
10 mM in DMSO
Smiles
O=C(OCOC(C(C)C)=O)N1[C@@H](CN(CC1)C(C2=NC(NC3=NNC(C4CC4)=C3)=C5C=C(C=CC5=N2)Cl)=O)C
Molecular Formula
C26H30ClN7O5
Molecular Weight
556.01
References & Citations
[1]Jing Guo, et al. Synthesis, bioconversion, pharmacokinetic and pharmacodynamic evaluation of N-isopropyl-oxy-carbonyloxymethyl prodrugs of CZh-226, a potent and selective PAK4 inhibitor. Eur J Med Chem. 2020 Jan 15;186:111878.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PAK4
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