IDO1-IN-2

IDO1-IN-2 (compound 16) is a potent and selective IDO1 inhibitor with IC50s of 81 nM, 59 nM (mouse) and 28 nM (rat), respectively. IDO1-IN-2 has anti-cancer activity[1].

Product Specifications

CAS Number

[2346614-58-0]

UNSPSC

12352005

Target

Indoleamine 2,3-Dioxygenase (IDO)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ido1-in-2.html

Solubility

10 mM in DMSO

Smiles

O/N=C(N[C@H]1CC2=C1C=C(F)C=C2)/C3=NON=C3NCC(NCCO)=O

Molecular Formula

C15H17FN6O4

Molecular Weight

364.33

References & Citations

[1]Zhang H, et al.Discovery of Amino-cyclobutarene-derived Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitors for Cancer Immunotherapy.ACS Med Chem Lett. 2019 Sep 18;10 (11) :1530-1536.