Propargyl-PEG4-Br
Propargyl-PEG4-Br is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG4-Br is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. Propargyl-PEG4-Br is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Product Specifications
CAS Number
[1308299-09-3]
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
ADC Linker; PROTAC Linkers
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/propargyl-peg4-br.html
Purity
97.0
Solubility
10 mM in DMSO
Smiles
C#CCOCCOCCOCCOCCBr
Molecular Formula
C11H19BrO4
Molecular Weight
295.17
Precautions
H302, H315, H319, H335
References & Citations
[1]Suzanne AKERS-RODRIGUEZ, et al. Compositions and methods for the treatment of bacterial infections. WO2019126353A2.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Non-cleavable Linker; PEG Linkers
Available Sizes
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PKR (Interferon-Induced Double-Stranded RNA-activated Protein Kinase, E2AK2, EIF 2 AK 1, EIF 2 AK 2, eIF-2A Protein Kinase 2, EIF2AK2, Interferon-Induced, P1, p68 Kinase, PRKR, Protein Kinase RNA-Activated)