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Glutathione arsenoxide

Glutathione arsenoxide (GSAO) is a potential anticancer agent and a tumour metabolism inhibitor. Glutathione arsenoxide targets Mitochondrial endomycin nucleotide transferase (ANT) . Glutathione arsenoxide causes cell proliferation arrest and cell death. Glutathione arsenoxide can be used to identify cell-surface proteins, such as Protein disulphide isomerase[1][2].

Product Specifications

CAS Number

1271726-51-2

Product Name Alternative

GSAO

UNSPSC

12352005

Hazard Statement

H301+H331-H410

Target

Mitochondrial Metabolism

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/glutathione-arsenoxide.html

Solubility

10 mM in DMSO

Smiles

O=C(O)CNC([C@H](CSCC(NC1=CC=C([As](O)O)C=C1)=O)NC(CC[C@@H](C(O)=O)N)=O)=O

Molecular Formula

C18H25AsN4O9S

Molecular Weight

548.40

Precautions

P261-P264-P270-P271-P273-P304+P340-P330-P391-P403+P233-P405-P501

References & Citations

[1]Habeck M. Australian scientists design novel antiangiogenic weapon[J]. The Lancet Oncology, 2000, 1 (4) : 199. |[2]Park D, et al. The tumour metabolism inhibitors GSAO and PENAO react with cysteines 57 and 257 of mitochondrial adenine nucleotide translocase. Cancer Cell Int. 2012 Mar 26;12 (1) :11.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Phase 1

Frequently Asked Questions

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