(±) 11 (12) -EET-d11
(±) 11 (12) -EET-d11 is the deuterium labeled (±) 11 (12) -EET. (±) 11 (12) -EET is a NLRP3 inflammasome inhibitor. (±) 11 (12) -EET can be used for the research of anti-inflammatory, angiogenic and cardioprotective[1][2][3][4][6].
Product Specifications
CAS Number
2699607-19-5
Product Name Alternative
(±) 11,12-EET-d11
UNSPSC
12352005
Target
NOD-like Receptor (NLR)
Type
Isotope-Labeled Compounds
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Concentration
301.63 μM * 100 μL in Ethanol
Purity
98.0
Smiles
[2H]C([2H])(C([2H])(/C=C\C[C@@H]1[C@H](C/C=C\C/C=C\CCCC(O)=O)O1)[2H])C([2H])(C([2H])(C([2H])([2H])[2H])[2H])[2H]
Molecular Formula
C20H21D11O3
Molecular Weight
331.53
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2] Luo XQ, et al. Epoxyeicosatrienoic acids inhibit the activation of NLRP3 inflammasome in murine macrophages. J Cell Physiol. 2020;235 (12) :9910-9921.|[3]Chacos N, et al. Novel epoxides formed during the liver cytochrome P-450 oxidation of arachidonic acid. Biochem Biophys Res Commun. 1982;104 (3) :916-922.|[4]Oliw EH, et al. Oxygenation of arachidonic acid by hepatic monooxygenases. Isolation and metabolism of four epoxide intermediates. J Biol Chem. 1982;257 (7) :3771-3781.|[5]Capdevila JH, et al. Cytochrome P450 and arachidonic acid bioactivation. Molecular and functional properties of the arachidonate monooxygenase. J Lipid Res. 2000;41 (2) :163-181.|[6]Wang Z, et al. Arachidonic acid inhibits basolateral K channels in the cortical collecting duct via cytochrome P-450 epoxygenase-dependent metabolic pathways. Am J Physiol Renal Physiol. 2008;294 (6) :F1441-F1447.|[7]Spector AA. Arachidonic acid cytochrome P450 epoxygenase pathway. J Lipid Res. 2009;50 Suppl (Suppl) :S52-S56.
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
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