HPB

HPB (HDAC6 inhibitor HPB) is a selective HDAC6 inhibitor with an IC50 of 31 nM. HPB exhibits >30-flod selectivity for HDAC6 over HDAC1[1].

Product Specifications

CAS Number

[1800066-24-3]

Product Name Alternative

HDAC6 inhibitor HPB

UNSPSC

12352005

Target

HDAC

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hpb.html

Purity

99.11

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N(CC1=CC=C(C(NO)=O)C=C1)CCO)CC2=CC=CC=C2

Molecular Formula

C18H20N2O4

Molecular Weight

328.36

References & Citations

[1]Nicholas J Porter, et al. Unusual zinc-binding mode of HDAC6-selective hydroxamate inhibitors. Proc Natl Acad Sci U S A. 2017 Dec 19;114 (51) :13459-13464.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

HDAC1; HDAC6

Available Sizes

Curated Selection

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