Protectin D1

Protectin D1, a neuroprotectin D1 produced by neuronal cells, is a member of a newly discovered family of bioactive products derived from docosahexaenoic acid. Protectin D1 also serves as a specialized pro-resolving mediator, exhibiting effective in vivo pro-resolving activity in various human disease models. Additionally, Protectin D1 is an inhibitor of NALP3 inflammasomes and regulates the PI3K/AKT and HIF-1α signaling pathways. Protectin D1 exerts anti-inflammatory effects by reducing ROS levels, inhibiting the expression of NALP3, ASC, and Caspase-1, and consequently decreasing the release of pro-inflammatory cytokines IL-1β and IL-18. Furthermore, Protectin D1 enhances miRNA-210 expression, activates the PI3K/AKT signaling pathway, and exerts cardioprotective effects. Protectin D1 holds promise for research in cardiovascular diseases and inflammatory disorders[1][2].

Product Specifications

CAS Number

[660430-03-5]

Product Name Alternative

Neuroprotectin D1; NPD1

UNSPSC

12352211

Target

Akt; Caspase; Endogenous Metabolite; HIF/HIF Prolyl-Hydroxylase; Interleukin Related; MicroRNA; PI3K; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Apoptosis; Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR

Applications

Neuroscience-Neuromodulation

Field of Research

Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/protectin-d1.html

Concentration

277.40 µM * 100 μL in Ethanol

Purity

99.10

Solubility

10 mM in DMSO

Smiles

CC/C=C\C[C@H](O)/C=C\C=C\C=C\[C@H](O)C/C=C\C/C=C\CCC(O)=O

Molecular Formula

C22H32O4

Molecular Weight

360.49

References & Citations

[1]Tungen JE, et al. Synthesis of protectin D1 analogs: novel pro-resolution and radiotracer agents. Org Biomol Chem. 2018;16 (36) :6818-6823.|[2]Serhan CN, et al. Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: assignments of dihydroxy-containing docosatrienes [published correction appears in J Immunol. 2006 Mar 15;176 (6) :3843]. J Immunol. 2006;176 (3) :1848-1859.|[3]Zhang P, et al. Protectin D1 Alleviates Myocardial Ischemia/Reperfusion Injury by Regulating PI3K/AKT Signaling Pathway. J Cardiovasc Transl Res. 2024 Apr;17 (2) :376-387.