8-Isoprostaglandin E2

8-Isoprostaglandin E2 (iPE2-III) is a member of the isoprostane class of prostanoids. 8-Isoprostaglandin E2 acts at the receptor for thromboxane A2 (the TP) in vivo to induce vasoconstriction and platelet aggregation. 8-Isoprostaglandin E2 enhances receptor-activated NFkappa B ligand (RANKL) -dependent osteoclastic potential of marrow hematopoietic precursors via the cAMP pathway[1][2].

Product Specifications

CAS Number

[27415-25-4]

Product Name Alternative

IPE2-III

UNSPSC

12352211

Hazard Statement

H302-H360

Target

Prostaglandin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/8-isoprostaglandin-e2.html

Purity

99.0

Solubility

10 mM in DMSO|DMSO : ≥ 100mg/mL

Smiles

CCCCC[C@H](O)/C=C/[C@@H]1[C@@H](C(C[C@H]1O)=O)C/C=C\CCCC(O)=O

Molecular Formula

C20H32O5

Molecular Weight

352.47

Precautions

P264-P270-P280-P330-P405-P501

References & Citations

[1]Wilson SJ, et al. Heterodimerization of the alpha and beta isoforms of the human thromboxane receptor enhances isoprostane signaling. Biochem Biophys Res Commun. 2007;352 (2) :397-403. |[2]Tintut Y, et al. 8-Isoprostaglandin E2 enhances receptor-activated NFkappa B ligand (RANKL) -dependent osteoclastic potential of marrow hematopoietic precursors via the cAMP pathway. J Biol Chem. 2002;277 (16) :14221-14226.