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PROTAC BCR-ABL1 ligand 1

PROTAC BCR-ABL1 ligand 1, compound GMB-475, is the ligand of PROTAC that allosterically targets BCR-ABL1 protein and recruits the E3 ligase Von Hippel-Lindau, resulting in ubiquitination and subsequent degradation of BCR-ABL1[1].

Product Specifications

CAS Number

2489876-34-6

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Bcr-Abl; Ligands for Target Protein for PROTAC

Type

Reference compound

Related Pathways

PROTAC; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/protac-bcr-abl1-ligand-1.html

Purity

99.17

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

OC1=CC=C(C2=NC=NC(NC3=CC=C(OC(F)(F)F)C=C3)=C2)C=C1

Molecular Formula

C17H12F3N3O2

Molecular Weight

347.29

Precautions

H302, H315, H319, H335

References & Citations

[1]Burslem GM, et al. Targeting BCR-ABL1 in Chronic Myeloid Leukemia by PROTAC-Mediated Targeted Protein Degradation. Cancer Res. 2019 Sep 15;79 (18) :4744-4753.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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