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Psoromic acid

Psoromic acid is a potent and selective RabGGTase (Rab geranylgeranyl transferase) inhibitor with an IC50 value of 1.3 µM. Psoromic acid is an antioxidative agent. Psoromic acid exhibits a competitive type of HMGR inhibition and mixed type of ACE (angiotensin converting enzyme) inhibition[1][2].

Product Specifications

CAS Number

[7299-11-8]

Product Name Alternative

Parellic acid

UNSPSC

12352005

Target

Others

Type

Natural Products

Related Pathways

Others

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/psoromic-acid.html

Purity

99.2

Solubility

DMSO : 7.17 mg/mL (ultrasonic; warming)

Smiles

OC(C(C=C1OC)=C(OC(C2=C3C)=C(C(O)=C3)C=O)C(OC2=O)=C1C)=O

Molecular Formula

C18H14O8

Molecular Weight

358.30

References & Citations

[1]Deraeve C, et al. Psoromic acid is a selective and covalent Rab-prenylation inhibitor targeting autoinhibited RabGGTase. J Am Chem Soc. 2012 May 2;134 (17) :7384-91.|[2]Behera BC, et al. Antioxidative and cardiovascular-protective activities of metabolite usnic acid and psoromic acid produced by lichen species Usnea complanata under submerged fermentation. Pharm Biol. 2012 Aug;50 (8) :968-79.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Natural Products

Clinical Information

No Development Reported

Curated Selection

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