MRT67307 (hydrochloride)
MRT67307 hydrochloride is a dual inhibitor of the IKKε and TBK-1 with IC50s of 160 and 19 nM, respectively[1]. MRT67307 hydrochloride also inhibits ULK1 and ULK2 with IC50s of 45 and 38 nM, respectively. MRT67307 hydrochloride also blocks autophagy in cells[2].
Product Specifications
CAS Number
2095432-39-4
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Autophagy; IKK; ULK
Type
Reference compound
Related Pathways
Autophagy; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/mrt67307-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
O=C(C1CCC1)NCCCNC2=NC(NC3=CC=CC(CN4CCOCC4)=C3)=NC=C2C5CC5.[H]Cl
Molecular Formula
C26H37ClN6O2
Molecular Weight
501.06
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IKKε; TBK1; ULK1; ULK2
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
