Tr-PEG8-OH

Tr-PEG8-OH is a non-cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tr-PEG8-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

Product Specifications

CAS Number

[1144113-16-5]

UNSPSC

12352203

Hazard Statement

H302-H315-H319-H335

Target

ADC Linker; PROTAC Linkers

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related; PROTAC

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/tr-peg8-oh.html

Solubility

10 mM in DMSO

Smiles

OCCOCCOCCOCCOCCOCCOCCOCCOC(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3

Molecular Formula

C35H48O9

Molecular Weight

612.75

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Adam M. Wawro, et al. Multigram chromatography-free synthesis of octa (ethylene glycol) p-toluenesulfonate. ORGANIC CHEMISTRY. 2016 Jul.|[2]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.