CCG-232964

CCG-232964 is an orally active inhibitor of Rho/MRTF/SRF. CCG-232964 inhibits LPA-induced CTGF gene expression[1].

Product Specifications

CAS Number

[2349373-70-0]

UNSPSC

12352005

Target

Ras; ROCK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton; GPCR/G Protein; MAPK/ERK Pathway; Stem Cell/Wnt; TGF-beta/Smad

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ccg-232964.html

Solubility

10 mM in DMSO

Smiles

O=C(O)CCCSC1=NN=C(C2=CC=C(C3CC3)C=C2Cl)O1

Molecular Formula

C15H15ClN2O3S

Molecular Weight

338.81

References & Citations

[1]Kahl, Dylan, et al. 5-Aryl-1,3,4-oxadiazol-2-ylthioalkanoic Acids: A Highly Potent New Class of Inhibitors of Rho/Myocardin-Related Transcription Factor (MRTF) /Serum Reponse Factor (SRF) -Mediated Gene Transcription as Potential Antifibrotic Agents for Scleroderma. Journal of Medicinal Chemistry, (), acs.jmedchem.8b01772–.