MsbA-IN-6
Product Specifications
UNSPSC Description
MsbA-IN-6 is a potent inhibitor of MsbA. MsbA-IN-6 is an antibiotic. Gram-negative ATP-binding cassette (ABC) transporter MsbA, an essential inner membrane protein, transports lipopolysaccharide from the inner leaflet to the periplasmic face of the inner membrane. MsbA-IN-6 kills Escherichia coli through inhibition of its ATPase and transport activity, with no loss of activity against clinical multidrug-resistant strains[1][2].
Target Antigen
Antibiotic; Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/msba-in-6.html
Solubility
10 mM in DMSO
Smiles
C[C@H](OC1=CC2=C(C(/C=C/C3=NNN=N3)=CC=C2C=C1)C4CC4)C5=C(C=CC=C5Cl)Cl
Molecular Weight
451.35
References & Citations
[1]Alexander MK, et al. Disrupting Gram-Negative Bacterial Outer Membrane Biosynthesis through Inhibition of the Lipopolysaccharide Transporter MsbA. Antimicrob Agents Chemother. 2018;62(11):e01142-18.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-130004/MsbA-IN-6-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-130004/
Clinical Information
No Development Reported
CAS Number
2909443-13-4
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