MsbA-IN-6

MsbA-IN-6 is a potent inhibitor of MsbA. MsbA-IN-6 is an antibiotic. Gram-negative ATP-binding cassette (ABC) transporter MsbA, an essential inner membrane protein, transports lipopolysaccharide from the inner leaflet to the periplasmic face of the inner membrane. MsbA-IN-6 kills Escherichia coli through inhibition of its ATPase and transport activity, with no loss of activity against clinical multidrug-resistant strains[1][2].

Product Specifications

CAS Number

[2909443-13-4]

UNSPSC

12352005

Target

Antibiotic; Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/msba-in-6.html

Solubility

10 mM in DMSO

Smiles

C[C@H](OC1=CC2=C(C(/C=C/C3=NNN=N3)=CC=C2C=C1)C4CC4)C5=C(C=CC=C5Cl)Cl

Molecular Formula

C24H20Cl2N4O

Molecular Weight

451.35

References & Citations

[1]Alexander MK, et al. Disrupting Gram-Negative Bacterial Outer Membrane Biosynthesis through Inhibition of the Lipopolysaccharide Transporter MsbA. Antimicrob Agents Chemother. 2018;62 (11) :e01142-18.