Clovoxamine

Clovoxamine (DU23811) (Compound 35) has binding affinity for serotonin transporter (SERT) (Ki: 61 nM) . Clovoxamine is a 5-HT and norepinephrine reuptake (NE) re-uptake inhibitor. Clovoxamine is an antidepressant[1][2][3].

Product Specifications

CAS Number

[54739-19-4]

Product Name Alternative

DU23811

UNSPSC

12352005

Target

5-HT Receptor; Serotonin Transporter

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/clovoxamine.html

Solubility

10 mM in DMSO

Smiles

COCCCC/C(C1=CC=C(C=C1)Cl)=N/OCCN

Molecular Formula

C14H21ClN2O2

Molecular Weight

284.78

References & Citations

[1]Staroń J, et al. Tuning the activity of known drugs via the introduction of halogen atoms, a case study of SERT ligands - Fluoxetine and fluvoxamine. Eur J Med Chem. 2021 Aug 5;220:113533.|[2]Saletu B, et al. Clovoxamine and fluvoxamine-2 biogenic amine re-uptake inhibiting antidepressants: quantitative EEG, psychometric and pharmacokinetic studies in man. J Neural Transm. 1980;49 (1-2) :63-86.|[3]de Jong GJ. The use of a pre-column for the direct high-performance liquid chromatographic determination of the anti-depressants clovoxamine and fluvoxamine in plasma. J Chromatogr. 1980 Aug 8;183 (2) :203-11.