Clovoxamine
Clovoxamine (DU23811) (Compound 35) has binding affinity for serotonin transporter (SERT) (Ki: 61 nM) . Clovoxamine is a 5-HT and norepinephrine reuptake (NE) re-uptake inhibitor. Clovoxamine is an antidepressant[1][2][3].
Product Specifications
CAS Number
54739-19-4
Product Name Alternative
DU23811
UNSPSC
12352005
Target
5-HT Receptor; Serotonin Transporter
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/clovoxamine.html
Solubility
10 mM in DMSO
Smiles
COCCCC/C(C1=CC=C(C=C1)Cl)=N/OCCN
Molecular Formula
C14H21ClN2O2
Molecular Weight
284.78
References & Citations
[1]Staroń J, et al. Tuning the activity of known drugs via the introduction of halogen atoms, a case study of SERT ligands - Fluoxetine and fluvoxamine. Eur J Med Chem. 2021 Aug 5;220:113533.|[2]Saletu B, et al. Clovoxamine and fluvoxamine-2 biogenic amine re-uptake inhibiting antidepressants: quantitative EEG, psychometric and pharmacokinetic studies in man. J Neural Transm. 1980;49 (1-2) :63-86.|[3]de Jong GJ. The use of a pre-column for the direct high-performance liquid chromatographic determination of the anti-depressants clovoxamine and fluvoxamine in plasma. J Chromatogr. 1980 Aug 8;183 (2) :203-11.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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