3,3'-Diiodo-L-thyronine-13C6

3,3'-Diiodo-L-thyronine-13C6 is the 13C labeled 3,3'-Diiodo-L-thyronine[1]. 3,3'-Diiodo-L-thyronine (3,3'-T2) is an endogenous metabolite of thyroid hormone. 3,3'-Diiodo-L-thyronine significantly enhances COX activity[2][3].

Product Specifications

CAS Number

[1217459-13-6]

Product Name Alternative

3,3'-T2-13C6

UNSPSC

12352005

Hazard Statement

H302

Target

COX; Endogenous Metabolite

Type

Isotope-Labeled Compounds

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/3-3-diiodo-l-thyronine-13c6.html

Solubility

10 mM in DMSO

Smiles

IC(C=C(C=C1)C[C@H](N)C(O)=O)=C1O[13C]2=[13CH][13C](I)=[13C]([13CH]=[13CH]2)O

Molecular Formula

C9 13C6H13I2NO4

Molecular Weight

531.03

Precautions

P264-P270-P330-P501

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Lorenzini L, et al. Assay of Endogenous 3,5-diiodo-L-thyronine (3,5-T2) and 3,3'-diiodo-L-thyronine (3,3'-T2) in Human Serum: A Feasibility Study. Front Endocrinol (Lausanne) . 2019 Feb 19;10:88.|[3]Lanni A, et al. Rapid stimulation in vitro of rat liver cytochrome oxidase activity by 3,5-diiodo-L-thyronine and by 3,3'-diiodo-L-thyronine. Mol Cell Endocrinol. 1994 Feb99 (1) :89-94.|[4]Chen X, et al. Simultaneous quantification of T4, T3, rT3, 3,5-T2 and 3,3'-T2 in larval zebrafish (Danio rerio) as a model to study exposure to polychlorinated biphenyls. Biomed Chromatogr. 2018 Jun32 (6) :e4185.