(S, R, S) -AHPC-C10-NH2 (dihydrochloride)
(S, R, S) -AHPC-C10-NH2 dihydrochloride (VH032-C10-NH2 dihydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S, R, S) -AHPC based VHL ligand and a linker used for BET-Targeted PROTAC[1].
Product Specifications
CAS Number
[2341796-75-4]
Product Name Alternative
VH032-C10-NH2 (dihydrochloride)
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/s-r-s-ahpc-c10-nh2-dihydrochloride.html
Purity
96.74
Solubility
DMSO : 250 mg/mL (ultrasonic) |H2O : 250 mg/mL (ultrasonic)
Smiles
NCCCCCCCCCCC(N[C@@H](C(C)(C)C)C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)=O.Cl.Cl
Molecular Formula
C33H53Cl2N5O4S
Molecular Weight
686.78
Precautions
H302, H315, H319, H335
References & Citations
[1]Pillow TH, et al. Antibody Conjugation of a Chimeric BET Degrader Enables in vivo Activity. ChemMedChem. 2019 Oct 31.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Von Hippel-Lindau (VHL)
Available Sizes
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