J-104129

J-104129 is a selective and orally active muscarinic M3 receptor antagonist (Ki = 4.2 nM) . J-104129 is effective in promoting bronchodilation[1][2].

Product Specifications

CAS Number

[244277-89-2]

UNSPSC

12352005

Target

MAChR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/j-104129.html

Solubility

10 mM in DMSO

Smiles

O=C(NC1CCN(CC/C=C(C)/C)CC1)[C@@](O)(C2CCCC2)C3=CC=CC=C3

Molecular Formula

C24H36N2O2

Molecular Weight

384.55

References & Citations

[1]Mitsuya M, et al. J-104129, a novel muscarinic M3 receptor antagonist with high selectivity for M3 over M2 receptors. Bioorg Med Chem. 1999 Nov;7 (11) :2555-67. |[2]Morihiro Mitsuya, et al. Discovery of a muscarinic M3 receptor antagonist with high selectivity for M3 over M2 receptors among 2-[ (1S,3S) -3-sulfonylaminocyclopentyl]phenylacetamide derivatives. Bioorg Med Chem. 2000, 8 (4) : 825-832.