J-104129
Product Specifications
UNSPSC Description
J-104129 is a selective and orally active muscarinic M3 receptor antagonist (Ki = 4.2 nM). J-104129 is effective in promoting bronchodilation[1][2].
Target Antigen
mAChR
Type
Reference compound
Related Pathways
GPCR/G Protein;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/j-104129.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1CCN(CC/C=C(C)/C)CC1)[C@@](O)(C2CCCC2)C3=CC=CC=C3
Molecular Weight
384.55
References & Citations
[1]Mitsuya M, et al. J-104129, a novel muscarinic M3 receptor antagonist with high selectivity for M3 over M2 receptors. Bioorg Med Chem. 1999 Nov;7(11):2555-67. |[2]Morihiro Mitsuya, et al. Discovery of a muscarinic M3 receptor antagonist with high selectivity for M3 over M2 receptors among 2-[(1S,3S)-3-sulfonylaminocyclopentyl]phenylacetamide derivatives. Bioorg Med Chem. 2000, 8(4): 825-832.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-129826/J-104129-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-129826/
Clinical Information
No Development Reported
CAS Number
244277-89-2
Curated Selection
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