J-104129
J-104129 is a selective and orally active muscarinic M3 receptor antagonist (Ki = 4.2 nM) . J-104129 is effective in promoting bronchodilation[1][2].
Product Specifications
CAS Number
244277-89-2
UNSPSC
12352005
Target
MAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/j-104129.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1CCN(CC/C=C(C)/C)CC1)[C@@](O)(C2CCCC2)C3=CC=CC=C3
Molecular Formula
C24H36N2O2
Molecular Weight
384.55
References & Citations
[1]Mitsuya M, et al. J-104129, a novel muscarinic M3 receptor antagonist with high selectivity for M3 over M2 receptors. Bioorg Med Chem. 1999 Nov;7 (11) :2555-67. |[2]Morihiro Mitsuya, et al. Discovery of a muscarinic M3 receptor antagonist with high selectivity for M3 over M2 receptors among 2-[ (1S,3S) -3-sulfonylaminocyclopentyl]phenylacetamide derivatives. Bioorg Med Chem. 2000, 8 (4) : 825-832.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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