Bis-ANS (dipotassium)
Product Specifications
UNSPSC Description
Bis-ANS dipotassium is a fluorescent probe of hydrophobic protein. Bis-ANS binds to tubulin with a Kd of 2 μM[1]. Bis-ANS dipotassium is a potent biphasic modulator of protein liquid-liquid phase separation (LLPS). Bis-ANS dipotassium promotes LLPS at low concentrations but suppresses LLPS at high concentrations[2].
Target Antigen
Microtubule/Tubulin
Type
Dye Reagents
Related Pathways
Cell Cycle/DNA Damage;Cytoskeleton
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/bis-ans-dipotassium.html
Purity
99.0
Solubility
DMSO : 30 mg/mL (ultrasonic;warming)
Smiles
O=S(C1=CC=CC2=C(C3=C4C=CC=C(S(=O)(O[K])=O)C4=C(NC5=CC=CC=C5)C=C3)C=CC(NC6=CC=CC=C6)=C12)(O[K])=O
Molecular Weight
672.85
References & Citations
[1]P Horowitz, et al. Bis(1,8-anilinonaphthalenesulfonate). A novel and potent inhibitor of microtubule assembly. J Biol Chem. 1984 Dec 10;259(23):14647-50.|[2]W. Michael Babinchak, et al. Small molecules as potent biphasic modulators of protein liquid-liquid phase separation. Nature Communications volume 11, Article number: 5574 (2020)
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-129811/Bis-ANS-dipotassium-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-129811/Bis-ANS-dipotassium-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
65664-81-5
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