PD 135158

PD 135158 (CAM 1028) is a selective CCKB receptor antagonist with an IC50 of 2.8 nM against mouse cortex CCKB. PD 135158 shows anxiolytic activity[1].

Product Specifications

CAS Number

[130325-35-8]

Product Name Alternative

CAM 1028

UNSPSC

12352005

Target

Cholecystokinin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/pd-135158.html

Solubility

10 mM in DMSO

Smiles

C[C@@](C1(C)C)(CC[C@@]1([H])C2)[C@@H]2OC(N[C@](C(NC[C@@H](C3=CC=CC=C3)NC(CCC(O)=O)=O)=O)(C)CC4=CNC5=CC=CC=C45)=O.O[C@H]([C@@H](O)CNC)[C@H](O)[C@H](O)CO

Molecular Formula

C42H61N5O11

Molecular Weight

811.96

References & Citations

[1]Hughes J, et al. Development of a class of selective cholecystokinin type B receptor antagonists having potent anxiolytic activity. Proc Natl Acad Sci U S A. 1990 Sep;87 (17) :6728-32.|[2]Gracey DJ, et al. PD-135,158, a cholecystokinin (B) antagonist, enhances latent inhibition in the rat. Pharmacol Biochem Behav. 2000 Mar;65 (3) :459-63.