PD 135158
PD 135158 (CAM 1028) is a selective CCKB receptor antagonist with an IC50 of 2.8 nM against mouse cortex CCKB. PD 135158 shows anxiolytic activity[1].
Product Specifications
CAS Number
130325-35-8
Product Name Alternative
CAM 1028
UNSPSC
12352005
Target
Cholecystokinin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pd-135158.html
Solubility
10 mM in DMSO
Smiles
C[C@@](C1(C)C)(CC[C@@]1([H])C2)[C@@H]2OC(N[C@](C(NC[C@@H](C3=CC=CC=C3)NC(CCC(O)=O)=O)=O)(C)CC4=CNC5=CC=CC=C45)=O.O[C@H]([C@@H](O)CNC)[C@H](O)[C@H](O)CO
Molecular Formula
C42H61N5O11
Molecular Weight
811.96
References & Citations
[1]Hughes J, et al. Development of a class of selective cholecystokinin type B receptor antagonists having potent anxiolytic activity. Proc Natl Acad Sci U S A. 1990 Sep;87 (17) :6728-32.|[2]Gracey DJ, et al. PD-135,158, a cholecystokinin (B) antagonist, enhances latent inhibition in the rat. Pharmacol Biochem Behav. 2000 Mar;65 (3) :459-63.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CCKAR; CCKBR
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