K-Ras ligand-Linker Conjugate 1
K-Ras ligand-Linker Conjugate 1 incorporates a ligand for K-Ras, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 1 can be used in the synthesis of PROTAC K-Ras Degrader-1 , which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells[1].
Product Specifications
CAS Number
2749492-84-8
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Target Protein Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/k-ras-ligand-linker-conjugate-1.html
Solubility
10 mM in DMSO
Smiles
O=C(N1CCOCCOCCOCCO[C@@H]2C[C@@H](COC3=NC4=C(CCNC4)C(N5CCN(C(OCC6=CC=CC=C6)=O)[C@@H](CC#N)C5)=N3)N(C)C2)C7=C(C=CC=C7)C1=O
Molecular Formula
C43H54N8O9
Molecular Weight
826.94
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]CREW, Andrew P., et al. MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE. WO2019195609A2.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Cytokeratin, LMW (AE-1), CF647 conjugate, 0.1mg/mL
CD45RO (UCHL-1), CF640R conjugate, 0.1mg/mL
Mucin 1 / EMA / Episialin / CD227 (VU-2G7), CF740 conjugate, 0.1mg/mL
Fibronectin (TV-1), CF488A conjugate, 0.1mg/mL
