Di-4-ANEPPS
Di-4-ANEPPS is a voltage-sensitive dye that acts on voltage-gated ion channels (such as sodium channels) and inhibits sodium current, significantly reducing sodium current density, although specific values like IC50 remain unclear. It mainly binds to the voltage-sensitive regions on the cell membrane, changing its fluorescence properties to reflect membrane potential changes and thus affecting the function of ion channels to exert its activity. This substance can be used in cardiovascular research, such as the electrophysiology of cardiomyocytes, myocardial ischemia, and the effects of drugs on cardiomyocytes. It is of great value in evaluating drug cardiotoxicity and exploring the mechanisms of arrhythmias[1][2].
Product Specifications
CAS Number
90134-00-2
UNSPSC
12171500
Target
Fluorescent Dye
Type
Dye Reagents
Related Pathways
Others
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/di-4-anepps.html
Purity
99.00
Solubility
10 mM in DMSO
Smiles
O=S(CCC[N+]1=CC=C(/C=C/C2=CC=C3C=C(N(CCCC)CCCC)C=CC3=C2)C=C1)([O-])=O
Molecular Formula
C28H36N2O3S
Molecular Weight
480.66
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Dye Reagents
Clinical Information
No Development Reported
Frequently Asked Questions
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