P32/98 (hemifumarate)

P32/98 hemifumarateis a potent inhibitor of dipeptidyl peptidase IV with a Ki value of 130 nM. P32/98 hemifumarate improves glucose tolerance, insulin sensitivity and β-cell responsiveness in fatty Zucker rat model[1][2][3].

Product Specifications

CAS Number

[251572-86-8]

UNSPSC

12352211

Target

Dipeptidyl Peptidase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/p32-98-hemifumarate.html

Solubility

10 mM in DMSO

Smiles

CC[C@H](C)[C@H](N)C(N1CSCC1)=O.O=C(O)/C=C/C(O)=O.[1/2]

Molecular Formula

C9H18N2OS.1/2C4H4O4

Molecular Weight

260.36

References & Citations

[1]Augstein P, et al. Efficacy of the dipeptidyl peptidase IV inhibitor isoleucine thiazolidide (P32/98) in fatty Zucker rats with incipient and manifest impaired glucose tolerance. Diabetes Obes Metab. 2008;10 (10) :850-861. |[2]Schlatter P, et al. Glucagon-like peptide 1 receptor expression in primary porcine proximal tubular cells. Regul Pept. 2007 Jun 7;141 (1-3) :120-8. |[3]Wargent E, et al. Improvement of glucose tolerance in Zucker diabetic fatty rats by long-term treatment with the dipeptidyl peptidase inhibitor P32/98: comparison with and combination with rosiglitazone. Diabetes Obes Metab. 2005;7 (2) :170-181.