MCL-1/BCL-2-IN-4
MCL-1/BCL-2-IN-4 (Compound 7) is a potent and selective Mcl-1 and Bcl-2 dual inhibitor[1].
Product Specifications
CAS Number
[2163793-56-2]
UNSPSC
12352005
Target
Bcl-2 Family
Type
Reference compound
Related Pathways
Apoptosis
Applications
Neuroscience-Neurodegeneration
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mcl-1-bcl-2-in-4.html
Purity
99.95
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(O)CCCCC(NCCN(C(C1=CC=C(SC2=CC=C(Br)C=C2)C3=CC=CC4=C13)=O)C4=O)=O
Molecular Formula
C26H23BrN2O5S
Molecular Weight
555.44
References & Citations
[1]Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem. 2019 Sep 12;62 (17) :8152-8163.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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