GS-389
GS 389 ((±) -O, O-Dimethylcoclaurine) is a tetrahydroisoquinoline. GS-389 inhibites Cyclic AMP and cyclic AMP dependent phosphodiesterases from rat atrial and ventricular tissue. GS-389 relaxes the contraction induced by phenylephrine and high K+ in rat aortic rings[1].
Product Specifications
CAS Number
41498-37-7
Product Name Alternative
(±) -O, O-Dimethylcoclaurine
UNSPSC
12352005
Target
Endogenous Metabolite
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/gs-389.html
Solubility
10 mM in DMSO
Smiles
COC1=CC=C(CC2NCCC3=C2C=C(OC)C(OC)=C3)C=C1
Molecular Formula
C19H23NO3
Molecular Weight
313.39
References & Citations
[1]Chang KC, et al. Different pharmacological characteristics of structurally similar benzylisoquinoline analogs, papaverine, higenamine, and GS 389, on isolated rat aorta and heart. Can J Physiol Pharmacol. 1994;72 (4) :327-334.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Frequently Asked Questions
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