GS-389
GS 389 ((±) -O, O-Dimethylcoclaurine) is a tetrahydroisoquinoline. GS-389 inhibites Cyclic AMP and cyclic AMP dependent phosphodiesterases from rat atrial and ventricular tissue. GS-389 relaxes the contraction induced by phenylephrine and high K+ in rat aortic rings[1].
Product Specifications
CAS Number
41498-37-7
Product Name Alternative
(±) -O, O-Dimethylcoclaurine
UNSPSC
12352005
Target
Endogenous Metabolite
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/gs-389.html
Solubility
10 mM in DMSO
Smiles
COC1=CC=C(CC2NCCC3=C2C=C(OC)C(OC)=C3)C=C1
Molecular Formula
C19H23NO3
Molecular Weight
313.39
References & Citations
[1]Chang KC, et al. Different pharmacological characteristics of structurally similar benzylisoquinoline analogs, papaverine, higenamine, and GS 389, on isolated rat aorta and heart. Can J Physiol Pharmacol. 1994;72 (4) :327-334.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
129238-HRP 100 µL
LSM16 (EDC3, YJDC, YJEFN2, Enhancer of mRNA-decapping Protein 3, LSM16 Homolog, YjeF N-terminal Domain-containing Protein 2, YjeF Domain-containing Protein 1, FLJ21128, FLJ31777) (HRP)
Sign In for Pricing
View Details TA800835BM 100 µL
ATP5F1C Mouse Monoclonal Antibody (HRP conjugated) [Clone ID: OTI2H6]
Sign In for Pricing
View Details 
R1171-01F-FITC 100 µL
Raptor, phosphorylated (Ser706) (Regulatory Associated Protein of mTOR, p150 Target of Rapamycin (TOR) Scaffold Protein containing WD-repeats, KIAA1303) (FITC) discontinued
Sign In for Pricing
View Details