NH2-PEG5-OH

NH2-PEG5-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. NH2-PEG5-OH is also a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [2].

Product Specifications

CAS Number

[34188-11-9]

UNSPSC

12352203

Hazard Statement

H302, H315, H319, H335

Target

ADC Linker; PROTAC Linkers

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/nh2-peg5-oh.html

Purity

99.82

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OCCOCCOCCOCCOCCN

Molecular Formula

C10H23NO5

Molecular Weight

237.29

Precautions

H302, H315, H319, H335

References & Citations

[1]Nathanael Gray, et al. Bifunctional molecules for degradation of egfr and methods of use. WO2017185036A1.|[2]Nianhe Han, et al. Derivatives of dolastatin 10 and uses thereof. WO2016192527A1.