(E/Z) -CLH304a
(E/Z) -CLH304a (GABAB receptor antagonist 1) is a mixture of (E) -CLH304a and (Z) -CLH304a. (E) -CLH304a (CLH304a; HY-129636) is a specific and noncompetitive GABAB receptor negative allosteric modulator (NAM). CLH304a inhibits Baclofen -induced ERK1/2 phosphorylation in HEK293 cells overexpressing GABAB receptors[1][2].
Product Specifications
CAS Number
797-17-1
Product Name Alternative
GABAB receptor antagonist 1
UNSPSC
12352005
Target
ERK; GABA Receptor
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; Membrane Transporter/Ion Channel; Neuronal Signaling; Stem Cell/Wnt
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/e-z-clh304a.html
Solubility
DMSO : ≥ 200 mg/mL
Smiles
O=C(O)C(/C=C/C1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1)=O
Molecular Formula
C18H24O4
Molecular Weight
304.38
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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