Repinotan

Repinotan (BAY x 3702 free base) is a potent, selective, brain-penetrant and orally active 5-HT1A receptor agonist, with Ki values of 0.19 nM (calf hippocampus), 0.25 nM (rat and human cortex), and 0.59 nM (rat hippocampus) . Repinotan has a weak affinity for other related receptors. Repinotan has pronounced neuroprotective effects[1].

Product Specifications

CAS Number

[144980-29-0]

Product Name Alternative

BAY x 3702 (free base)

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/repinotan.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=C2C=CC=C1)N(CCCCNC[C@H]3CCC4=CC=CC=C4O3)S2(=O)=O

Molecular Formula

C21H24N2O4S

Molecular Weight

400.49

References & Citations

[1] A C Berends, et al. A review of the neuroprotective properties of the 5-HT1A receptor agonist repinotan HCl (BAYx3702) in ischemic stroke. CNS Drug Rev. Winter 2005;11 (4) :379-402.