Dinoprost-d4

Dinoprost-d4 is the deuterium labeled Dinoprost. Dinoprost (Prostaglandin F2α) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist. Dinoprost is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL) . Dinoprost plays a key role in the onset and progression of labour[1][2].

Product Specifications

CAS Number

[34210-11-2]

Product Name Alternative

Prostaglandin F2a-d4; PGF2α-d4

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Autophagy; Endogenous Metabolite; Isotope-Labeled Compounds; Prostaglandin Receptor

Type

Isotope-Labeled Compounds

Related Pathways

Apoptosis; Autophagy; GPCR/G Protein; Metabolic Enzyme/Protease; Others

Field of Research

Endocrinology

Concentration

278.93 μM * 250 μL in Methyl acetate

Purity

99.9

Solubility

10 mM in DMSO

Smiles

OC(CC([2H])([2H])C([2H])([2H])/C=C\C[C@@H]([C@H](C1)O)[C@H]([C@@H]1O)/C=C/[C@@H](O)CCCCC)=O

Molecular Formula

C20H30D4O5

Molecular Weight

358.51

Precautions

H302, H315, H319, H335

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Hagen Thieme, et al. Endothelin antagonism: effects of FP receptor agonists prostaglandin F2alpha and fluprostenol on trabecular meshwork contractility. Invest Ophthalmol Vis Sci. 2006 Mar;47 (3) :938-45.|[3]Xin Wen, et al. Prostaglandin F2α Induces Goat Corpus Luteum Regression via Endoplasmic Reticulum Stress and Autophagy. Front Physiol. 2020 Sep 11;11:868.