UK-1
UK-1 is a cytotoxic metabolite from Streptomyces sp. 517-02 and exerts a wide spectrum of potent anticancer activities[1]. UK-1 also inhibits HCV replication[2].
Product Specifications
CAS Number
151271-53-3
UNSPSC
12352005
Hazard Statement
H302+H332-H319
Target
HCV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/uk-1.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C2N=C(C3=C4N=C(C5=CC=CC=C5O)OC4=CC=C3)OC2=CC=C1)OC
Molecular Formula
C22H14N2O5
Molecular Weight
386.36
Precautions
P261-P264-P270-P271-P280-P304+P340-P305+P351+P338-P330-P501
References & Citations
[1]Ueki M, et al. UK-1, a novel cytotoxic metabolite from Streptomyces sp. 517-02. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties. J Antibiot (Tokyo) . 1993 Jul;46 (7) :1089-94.|[2]Ward DN, et al. UK-1 and structural analogs are potent inhibitors of hepatitis C virus replication. Bioorg Med Chem Lett. 2014 Jan 15;24 (2) :609-12.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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