UK-1

UK-1 is a cytotoxic metabolite from Streptomyces sp. 517-02 and exerts a wide spectrum of potent anticancer activities[1]. UK-1 also inhibits HCV replication[2].

Product Specifications

CAS Number

[151271-53-3]

UNSPSC

12352005

Hazard Statement

H302+H332-H319

Target

HCV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/uk-1.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=C2N=C(C3=C4N=C(C5=CC=CC=C5O)OC4=CC=C3)OC2=CC=C1)OC

Molecular Formula

C22H14N2O5

Molecular Weight

386.36

Precautions

P261-P264-P270-P271-P280-P304+P340-P305+P351+P338-P330-P501

References & Citations

[1]Ueki M, et al. UK-1, a novel cytotoxic metabolite from Streptomyces sp. 517-02. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties. J Antibiot (Tokyo) . 1993 Jul;46 (7) :1089-94.|[2]Ward DN, et al. UK-1 and structural analogs are potent inhibitors of hepatitis C virus replication. Bioorg Med Chem Lett. 2014 Jan 15;24 (2) :609-12.