Ala-Ala-Asn-PAB
Ala-Ala-Asn-PAB is a peptide cleavable ADC linker for antibody-drug conjugates (ADCs) [1].
Product Specifications
CAS Number
[2149584-00-7]
UNSPSC
12352203
Hazard Statement
H302-H315-H319-H335
Target
ADC Linker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ala-ala-asn-pab.html
Solubility
10 mM in DMSO
Smiles
OCC1=CC=C(NC([C@H](CC(N)=O)NC([C@H](C)NC([C@@H](N)C)=O)=O)=O)C=C1
Molecular Formula
C17H25N5O5
Molecular Weight
379.41
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]Cheng X, et al. MORAb-202, an Antibody-Drug Conjugate Utilizing Humanized Anti-human FRα Farletuzumab and the Microtubule-targeting Agent Eribulin, has Potent Antitumor Activity. Mol Cancer Ther. 2018 Dec;17 (12) :2665-2675.
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Cleavable Linker
Curated Selection
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