Abemaciclib metabolite M20-d8
Abemaciclib metabolite M20-d8 is the deuterium labeled Abemaciclib metabolite M20. Abemaciclib metabolite M20 (LSN3106726), the active metabolite of Abemaciclib, is a selective CDK4/6 inhibitor[1].
Product Specifications
Product Name Alternative
LSN3106726-d8
UNSPSC
12352005
Target
CDK
Type
Isotope-Labeled Compounds
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Purity
99.26
Solubility
DMSO : 5mg/mL (ultrasonic)
Smiles
CC(C)N1C2=CC(C3=C(C=NC(NC4=NC=C(C=C4)CN(C([2H])(C5([2H])[2H])[2H])C([2H])(C([2H])(N5CC)[2H])[2H])=N3)F)=CC(F)=C2N=C1CO
Molecular Formula
C27H24D8F2N8O
Molecular Weight
530.64
References & Citations
[1]Morschhauser F, et al. Clinical activity of abemaciclib in patients with relapsed or refractory mantle cell lymphoma - a phase II study. Haematologica. 2021;106 (3) :859-862. Published 2021 Mar 1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
CDK4; CDK6
Frequently Asked Questions
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