Abemaciclib metabolite M20-d8

Abemaciclib metabolite M20-d8 is the deuterium labeled Abemaciclib metabolite M20. Abemaciclib metabolite M20 (LSN3106726), the active metabolite of Abemaciclib, is a selective CDK4/6 inhibitor[1].

Product Specifications

Product Name Alternative

LSN3106726-d8

UNSPSC

12352005

Target

CDK

Type

Isotope-Labeled Compounds

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Cancer

Purity

99.26

Solubility

DMSO : 5mg/mL (ultrasonic)

Smiles

CC(C)N1C2=CC(C3=C(C=NC(NC4=NC=C(C=C4)CN(C([2H])(C5([2H])[2H])[2H])C([2H])(C([2H])(N5CC)[2H])[2H])=N3)F)=CC(F)=C2N=C1CO

Molecular Formula

C27H24D8F2N8O

Molecular Weight

530.64

References & Citations

[1]Morschhauser F, et al. Clinical activity of abemaciclib in patients with relapsed or refractory mantle cell lymphoma - a phase II study. Haematologica. 2021;106 (3) :859-862. Published 2021 Mar 1.